Preprint link here.

Abstract: The integration of large language models (LLMs) into the medical field has gained significant attention due to their promising accuracy in simulated clinical decision-making settings. However, clinical decision-making is more complex than simulations because physicians’ decisions are shaped by many factors, including the presence of cognitive bias. However, the degree to which LLMs are susceptible to the same cognitive biases that affect human clinicians remains unexplored. Our hypothesis posits that when LLMs are confronted with clinical questions containing cognitive biases, they will yield significantly less accurate responses compared to the same questions presented without such biases.In this study, we developed BiasMedQA, a novel benchmark for evaluating cognitive biases in LLMs applied to medical tasks. Using BiasMedQA we evaluated six LLMs, namely GPT-4, Mixtral-8x70B, GPT-3.5, PaLM-2, Llama 2 70B-chat, and the medically specialized PMC Llama 13B. We tested these models on 1,273 questions from the US Medical Licensing Exam (USMLE) Steps 1, 2, and 3, modified to replicate common clinically-relevant cognitive biases. Our analysis revealed varying effects for biases on these LLMs, with GPT-4 standing out for its resilience to bias, in contrast to Llama 2 70B-chat and PMC Llama 13B, which were disproportionately affected by cognitive bias. Our findings highlight the critical need for bias mitigation in the development of medical LLMs, pointing towards safer and more reliable applications in healthcare.